De'Zhaun Stribling played in a preseason game and performed well with the offense.
That said, treat this as a small, early data point rather than a locked-in role. Preseason production from wide receivers is notoriously unreliable as a predictor of regular-season usage — target competition, depth chart shakeups, and roster cuts still loom before Week 1. The reporting here is descriptive of what happened on the field, not speculative about his ceiling, so you can trust the "he played well" part with reasonable confidence; what you can't yet trust is how that translates to actual snap share or target volume once the games count.
For draft prep, this is a name worth stashing on your watchlist rather than a player to reach for. In deep or dynasty formats, he's a very late-round flier or priority free-agent-monitor candidate — someone to circle for waiver-wire attention once roster cuts and depth charts clarify. In shallower season-long leagues, there's no actionable draft capital to spend yet; wait for further practice reports, snap counts, or beat-writer confirmation of his role before committing a pick. Confidence in the underlying report is decent, but confidence in fantasy relevance remains low until more preseason and roster news arrives.
Many 49ers who are expected to play roles for the team this fall did not play on Thursday night, but rookie wide receiver De'Zhaun Stribling was on the field and the second-round pick took advantage of the opportunity.